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Cortisol Single saliva sample collection kit
Saliva collection close-up
Laboratory work scene
Functional Health • Saliva based
Cortisol

Cortisol Single

Cortisol, a hormone released by the adrenal glands, follows a natural diurnal rhythm, peaking in the early morning and tapering through the afternoon and evening. Under normal conditions, cortisol levels peak in the early morning, helping regulate energy, blood pressure, immune response, and stress adaptation.

This test measures the free biologically active cortisol in a single saliva sample collected in the morning offering a noninvasive way to assess baseline adrenal function and identify possible HPA axis dysregulation. This single salivary test offers a convenient screening tool in both preventive care and follow-up settings.

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Key features

  • Morning (AM) cortisol level measurement
  • Noninvasive saliva sample collection
  • Consistent, accurate, & dependable molecular testing
  • Actionable clinical insights
View Sample Report Watch Saliva Collection Instruction Video Provider Fact Sheet (PDF)

A simple baseline view of adrenal function.

Morning cortisol is an important anchor point in the body’s daily rhythm. A single AM measurement can help provide a convenient baseline screen for adrenal function and stress adaptation—especially when paired with symptoms, history, and follow-up testing.

Because saliva reflects “free” cortisol (the biologically active form), it offers a noninvasive alternative to support preventive care and follow-up settings.

Download Provider Fact Sheet
Collect
Single AM saliva sample
Collected in the morning to capture the natural daily peak window.
Measure
Free cortisol
Evaluates the biologically active cortisol available for use by the body.
Use
Baseline screening
Supports preventive care conversations and follow-up decisions when needed.

What Cortisol Single measures

Cortisol Single measures free biologically active cortisol from one morning saliva sample—providing an accessible baseline snapshot of adrenal output.

If you want the exact recommended collection time language (ex: “upon waking” vs “6–8 AM”), tell me which wording you want and I’ll lock it in.

Included measurement
  • CortisolFree / active
  • SampleMorning (AM)
Single-sample baseline screen for morning cortisol.

When to test

Cortisol Single is a convenient option when you want a baseline cortisol snapshot and a low-lift collection workflow.

  • Initial screening for stress/adrenal rhythm concerns.
  • Fatigue, low energy, or reduced stress tolerance discussions.
  • Follow-up monitoring where a single baseline point is sufficient.
  • Patients who prefer a simple, noninvasive collection process.
  • When you want a starting point before expanded multi-point testing.

How it works

A streamlined single-sample workflow designed for convenience.

1

Collect in the morning

Collect one saliva sample in the AM using the included kit materials.

2

Ship to the lab

Package the sample and send it to the lab using the provided instructions.

3

Review results

Access results in the SimplyTest Provider Portal to support clinical decisions.